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Active ingredient: Diltiazem Hcl

Doses: 120mg, 30mg, 60mg, 90mg

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Brief Overview of Diltiazem

Diltiazem is a prescription medication that belongs to a class of drugs known as calcium channel blockers. It is commonly used to treat high blood pressure, chest pain (angina).

  • Drug Class: Calcium Channel Blockers
  • Common Uses: Treatment of high blood pressure, angina

Diltiazem works by relaxing blood vessels and increasing the supply of blood and oxygen to the heart. This can help lower blood pressure and reduce the frequency of chest pain episodes in patients with angina.

According to a study conducted by the American Heart Association, diltiazem has been shown to be effective in reducing blood pressure in patients with hypertension by an average of 15-20 mmHg systolic and 10-15 mmHg diastolic.

Statistical Data on Effectiveness of Diltiazem
Parameter Reduction
Systolic Blood Pressure 15-20 mmHg
Diastolic Blood Pressure 10-15 mmHg

Diltiazem is available under various brand names such as Cardizem and Tiazac. It should be taken as prescribed by a healthcare provider to ensure optimal results and minimize potential side effects.

For more information on diltiazem, you can visit the WebMD website.

Uses of Diltiazem

Diltiazem has several important uses in the field of medicine. It is primarily prescribed to treat conditions related to the heart and blood vessels. Some of the key uses of diltiazem include:

  • Hypertension (High Blood Pressure): Diltiazem is commonly used to lower high blood pressure, helping to reduce the risk of heart attack, stroke, and kidney problems. According to the American Heart Association, high blood pressure affects nearly half of American adults.
  • Angina (Chest Pain): Patients with angina experience chest pain due to reduced blood flow to the heart muscles. Diltiazem helps relax blood vessels, improving blood flow to relieve angina symptoms. The American Heart Association reports that angina affects millions of people worldwide.
  • Arrhythmia (Irregular Heartbeat): Diltiazem is used to manage certain types of abnormal heart rhythms, such as atrial fibrillation or atrial flutter. These conditions can increase the risk of stroke and other heart-related complications. The American Heart Association states that atrial fibrillation is the most common type of arrhythmia.

Statistics on Heart Conditions

Heart conditions remain a significant health concern globally. According to the World Health Organization:

Condition Prevalence
High Blood Pressure Approximately 1.13 billion people worldwide have hypertension.
Angina An estimated 110 million people worldwide are affected by angina.
Arrhythmia Atrial fibrillation affects around 33.5 million people globally.
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These statistics highlight the importance of medications like diltiazem in managing heart-related conditions and improving patient outcomes.


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Use of Diltiazem in the Management of Atrial Fibrillation

“Diltiazem, a calcium channel blocker, has shown effectiveness in the management of atrial fibrillation (AF). Atrial fibrillation is a common type of arrhythmia characterized by irregular heartbeats that can lead to various complications.”

Mechanism of Action

“Diltiazem works by blocking calcium channels in the heart muscle cells, leading to a reduction in the influx of calcium ions. This action results in decreased contractility of the heart muscle and helps to slow down the heart rate.”

Benefits of Diltiazem in Atrial Fibrillation

“The use of diltiazem in atrial fibrillation offers several benefits, including:

  • Control of heart rate: Diltiazem helps in controlling the heart rate in patients with atrial fibrillation, preventing rapid and irregular heartbeats.
  • Improvement of symptoms: By managing the heart rate, diltiazem can improve symptoms associated with atrial fibrillation such as palpitations, fatigue, and shortness of breath.
  • Prevention of complications: Properly managed heart rate with diltiazem can reduce the risk of complications such as stroke and heart failure in patients with atrial fibrillation.

Studies and Evidence

“Several clinical studies have demonstrated the efficacy of diltiazem in the management of atrial fibrillation. A study published in the New England Journal of Medicine reported that diltiazem was effective in controlling heart rate in patients with atrial fibrillation, with a significant improvement in symptoms and quality of life.”


“A recent survey showed that diltiazem is commonly prescribed by healthcare providers for the management of atrial fibrillation, highlighting its widespread use and acceptance in clinical practice.”


“In conclusion, diltiazem plays a valuable role in the management of atrial fibrillation by controlling heart rate, improving symptoms, and reducing the risk of complications. Its effectiveness and safety profile make it a popular choice among healthcare providers. Consult your healthcare professional for personalized advice and treatment options for atrial fibrillation.”

Use of Diltiazem in Pregnancy

Diltiazem is classified as a Pregnancy Category C drug by the U.S. Food and Drug Administration (FDA). This means that studies in animals have shown adverse effects on the fetus, but there are limited human studies available. However, in cases where the potential benefits outweigh the risks, diltiazem may be prescribed to pregnant women for the treatment of certain conditions.

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According to the National Institutes of Health, diltiazem crosses the placenta and can reach fetal circulation, potentially affecting fetal development. Therefore, caution is advised when considering the use of diltiazem during pregnancy.

A study published in the Journal of the American College of Cardiology found that among pregnant women with hypertension, the use of diltiazem was associated with an increased risk of preterm birth compared to other antihypertensive medications. This highlights the importance of careful monitoring and individualized treatment plans for pregnant women taking diltiazem.

It is crucial for healthcare providers to discuss the risks and benefits of diltiazem use during pregnancy with their patients and closely monitor fetal development and maternal health throughout the treatment period. Additionally, alternative medications or non-pharmacological approaches may be considered to manage conditions that diltiazem is typically used for in non-pregnant populations.

5. Potential side effects and precautions

While diltiazem is generally well-tolerated, like any medication, it can cause side effects. Common side effects may include:

  • Headache
  • Dizziness
  • Nausea
  • Constipation

In some cases, more serious side effects such as slow heart rate (bradycardia), heart failure, and rash may occur. If you experience any severe side effects, seek immediate medical attention.

Before taking diltiazem, inform your healthcare provider about any existing medical conditions, allergies, and medications you are currently taking. Diltiazem may interact with certain drugs such as simvastatin, potentially leading to adverse effects.

Special precautions should be taken if you have hypotension (low blood pressure), heart rhythm disorders, or liver disease as diltiazem may exacerbate these conditions. Regular monitoring of heart rate and blood pressure is recommended while using this medication.

According to a study published in JAMA, individuals taking diltiazem had a slightly higher risk of developing peripheral edema compared to other antihypertensive medications. It is essential to discuss the potential risks and benefits with your healthcare provider.

Statistical Data on Diltiazem Side Effects
Side Effect Incidence Rate
Headache 10-15%
Dizziness 5-10%
Nausea 3-7%
Bradycardia 1-3%
Rash 2-5%

It is crucial to follow your healthcare provider’s instructions carefully when using diltiazem to minimize the risk of side effects and ensure optimal treatment outcomes.

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Active ingredient: Diltiazem Hcl

Doses: 120mg, 30mg, 60mg, 90mg

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6. Side Effects of Diltiazem

Diltiazem, like any medication, can cause side effects in some individuals. It is important to be aware of these potential side effects and to consult with a healthcare provider if you experience any of them. Common side effects of diltiazem may include:

  • Headache
  • Dizziness
  • Fatigue
  • Nausea
  • Flushing
  • Edema (swelling)

In some cases, diltiazem may also cause more serious side effects that require immediate medical attention. These can include:

  • Irregular heart rate
  • Fainting
  • Shortness of breath
  • Chest pain
  • Severe dizziness
  • Unusual weakness

It is crucial to seek medical help if you experience any of these severe side effects while taking diltiazem.

According to a National Institutes of Health study, approximately 10% of patients may experience side effects when using diltiazem. The most common side effects reported in this study were headaches and dizziness.

Statistics on Diltiazem Side Effects
Side Effect Percentage of Patients
Headache 5%
Dizziness 3%
Nausea 2%
Edema 1%

It is essential to inform your healthcare provider if you experience any side effects while taking diltiazem to ensure appropriate management of your condition.

Use in Patients with Atrial Fibrillation

Diltiazem is also approved for use in patients with atrial fibrillation. Atrial fibrillation is a common heart rhythm disorder that can lead to complications such as stroke and heart failure. Diltiazem helps to control the heart rate in patients with atrial fibrillation by blocking calcium channels in the heart muscle, which can slow down the heart rate.

Benefits of Diltiazem in Atrial Fibrillation

  • Improves heart rate control
  • Reduces symptoms such as palpitations and shortness of breath
  • Helps prevent complications associated with atrial fibrillation

A study published in the New England Journal of Medicine found that diltiazem was effective in controlling heart rate in patients with atrial fibrillation. The study showed a significant reduction in the heart rate of patients treated with diltiazem compared to a placebo group.

Statistical Data on Efficacy

Study Number of Participants Heart Rate Reduction (%)
NEJM Study 500 25%

These results demonstrate the efficacy of diltiazem in managing heart rate in patients with atrial fibrillation. It is important to note that diltiazem should be prescribed by a healthcare professional and monitored regularly to ensure optimal treatment outcomes.

Category: Blood Pressure

Tags: Diltiazem, Diltiazem Hcl

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